| UniProt Protein Function: | RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08116 |
| NCBI GenInfo Identifier: | 229470360 |
| NCBI Gene ID: | 5996 |
| NCBI Accession: | Q08116.3 |
| UniProt Secondary Accession: | Q08116,Q07918, Q9H1W2, B2RDM9, B4DZY0, |
| UniProt Related Accession: | Q08116 |
| Molecular Weight: | 19,134 Da |
| NCBI Full Name: | Regulator of G-protein signaling 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 1 |
| NCBI Official Symbol: | RGS1Â Â |
| NCBI Official Synonym Symbols: | 1R20; BL34; IER1; IR20; HEL-S-87Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 1 |
| UniProt Protein Name: | Regulator of G-protein signaling 1 |
| UniProt Synonym Protein Names: | B-cell activation protein BL34 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS1Â Â |
| UniProt Entry Name: | RGS1_HUMAN |
