The RGS1 Polyclonal Antibody (PAC02347) is a versatile tool for researchers studying RGS1, a key regulator of G protein signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for Western blot applications. By targeting the RGS1 protein, this antibody enables precise detection and analysis in a variety of cell types, offering valuable insights into the role of RGS1 in cellular signaling and potential therapeutic applications.RGS1, a member of the RGS protein family, is known for its ability to modulate G protein-coupled receptor signaling, thereby influencing various cellular processes including cell proliferation, migration, and differentiation.
Dysregulation of RGS1 has been implicated in a number of diseases, making it a promising therapeutic target for conditions such as cardiovascular disorders, neurological diseases, and cancer. By investigating the function of RGS1 using this antibody, researchers can uncover new pathways for drug development and precision medicine approaches.
Synthesized peptide derived from internal of human RGS1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from mouse muscle cells, using RGS1 antibody.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using RGS1 antibody.
Background:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
Synonyms:
RGS1; Early response protein 1R20; B-cell activation protein BL34;
UniProt Protein Function:
RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction
NCBI Summary:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
