The RGS1 Polyclonal Antibody (PACO16973) is a valuable tool for researchers studying the function of RGS1, a protein involved in immune regulation and cell signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot experiments. By targeting the RGS1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in immunology and cancer research.RGS1, also known as Regulator of G protein Signaling 1, plays a crucial role in modulating immune responses and cell signaling cascades. Its involvement in regulating immune cell activation and migration makes it a key player in the development of therapies for autoimmune disorders, inflammatory diseases, and cancer.
By studying the function of RGS1, researchers can gain insight into potential targets for novel treatments aimed at manipulating immune responses in various disease states.Overall, the RGS1 Polyclonal Antibody (PACO16973) offers researchers a reliable tool for exploring the role of RGS1 in immune regulation and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for advancing our understanding of immune function and identifying potential therapeutic targets for a range of conditions.
Antibody Name:
RGS1 Antibody (PACO16973)
Antibody SKU:
PACO16973
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human RGS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16973(RGS1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid, motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G α subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP.
Synonyms:
regulator of G-protein signaling 1
UniProt Protein Function:
RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction
NCBI Summary:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
