The RGS1 Monoclonal Antibody (PAC016972) is a valuable tool for researchers studying the regulator of G protein signaling 1 (RGS1) protein. This antibody, generated in mice, specifically targets RGS1 and is highly reactive with human samples. It has been validated for use in various applications, including Western blotting and immunohistochemistry.RGS1 is an important regulator of G protein signaling, playing a key role in modulating immune responses and inflammation. Dysregulation of RGS1 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By targeting RGS1 with this antibody, researchers can gain insights into the function and regulation of this protein in different cell types and disease contexts.Overall, the RGS1 Monoclonal Antibody (PAC016972) is a valuable tool for researchers interested in understanding the role of RGS1 in immune regulation and disease pathology. Its specificity and reactivity make it ideal for a wide range of research applications, contributing to advancements in immunology and cancer research.
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: PACO16972(RGS1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16972(RGS1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid, motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G α subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G α subunits to bind G beta/γ subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Synonyms:
regulator of G-protein signaling 1
UniProt Protein Function:
RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction
NCBI Summary:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
