The RFC2 Polyclonal Antibody (CAB6847) is a valuable tool for researchers studying RFC2, a protein involved in DNA replication and repair processes. This high-quality antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for Western blot applications. By specifically binding to the RFC2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for use in molecular biology and cancer research studies.RFC2, also known as Replication Factor C Subunit 2, plays a crucial role in maintaining genomic stability and ensuring accurate DNA replication.
Dysregulation of RFC2 has been associated with various diseases, including cancer and genetic disorders. Investigating the function and regulation of RFC2 is essential for advancing our understanding of these conditions and developing potential therapeutic interventions.In summary, the RFC2 Polyclonal Antibody (CAB6847) offers researchers a reliable tool for investigating the role of RFC2 in cellular processes and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for advancing scientific knowledge in the fields of genomics and oncology.
Product Name:
RFC2 Rabbit Polyclonal Antibody
SKU:
CAB6847
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-297 of human RFC2 (NP_852136.1).
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
5982
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RFC2 antibody (CAB6847) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
