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Retinoic Acid Receptor beta Transcription Factor Activity Assay

SKU:
TFAB00172
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Retinoic Acid Receptor beta
Reactivity:
Human
Mouse
€599
Frequently bought together:

Description

system_update_altDatasheet

Retinoic Acid Receptor beta Transcription Factor Activity Assay

The Retinoic Acid Receptor Beta Transcription Factor Activity Assay Kit is a powerful tool for studying the activity of the retinoic acid receptor beta transcription factor in various biological samples. This kit offers high sensitivity and specificity, allowing for accurate and reproducible results in serum, plasma, and cell culture supernatants.The retinoic acid receptor beta transcription factor plays a crucial role in gene expression regulation, cell differentiation, and development. Dysregulation of this transcription factor has been linked to various diseases, including cancer, inflammatory conditions, and neurological disorders.

The ability to measure its activity accurately provides valuable insights for understanding disease mechanisms and potential therapeutic interventions.With easy-to-follow protocols and high-performance components, the Retinoic Acid Receptor Beta Transcription Factor Activity Assay Kit is an essential tool for researchers and clinicians looking to investigate the role of this transcription factor in health and disease.

Product Name:Retinoic Acid Receptor beta Transcription Factor Activity Assay
Product Code:TFAB00172
Target:Retinoic Acid Receptor beta
Synonyms:HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon
Reactivity:Human, Mouse
Sample Types:Nuclear or cell lysates

The Assay Genie Retinoic Acid Receptor beta transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:RARB: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Oncoprotein; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; protein complex binding; steroid hormone receptor activity; drug binding; retinoic acid receptor activity

Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of myelination; glandular epithelial cell development; striatum development; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; positive regulation of neuron differentiation; embryonic gut development; transmembrane transport; negative regulation of apoptosis

Disease: Microphthalmia, Syndromic 12

NCBI Summary:This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:P10826
NCBI GenInfo Identifier:17380507
NCBI Gene ID:5915
NCBI Accession:P10826.2
UniProt Secondary Accession:P10826,P12891, Q00989, Q15298, Q9UN48,
UniProt Related Accession:P10826
Molecular Weight:– Da
NCBI Full Name:Retinoic acid receptor beta
NCBI Synonym Full Names:retinoic acid receptor, beta
NCBI Official Symbol:RARB  
NCBI Official Synonym Symbols:HAP; RRB2; NR1B2; MCOPS12  
NCBI Protein Information:retinoic acid receptor beta; RAR-beta; RAR-epsilon; HBV-activated protein; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2
UniProt Protein Name:Retinoic acid receptor beta
UniProt Synonym Protein Names:HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon
Protein Family:Retinoic acid receptor
UniProt Gene Name:RARB  
UniProt Entry Name:RARB_HUMAN
Antibodies
Anti-RARB Antibody (CAB13173)
Anti-RARB Antibody (CAB1603)
Anti-Retinoic Acid Receptor beta Antibody (CAB4535)
RARB Antibody (PACO01411)
RARB Antibody (PACO11724)

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