The Retinoic Acid Receptor Alpha Rabbit Monoclonal Antibody (CAB19551) is a valuable tool for researchers studying retinoic acid receptor alpha (RARα), a nuclear receptor protein that plays a key role in gene regulation and cellular differentiation. This antibody, raised in rabbits, is highly specific and sensitive for detecting RARα in human samples, making it suitable for use in Western blotting and immunohistochemistry applications.RARα is a crucial transcription factor that mediates the biological effects of retinoic acid, a vitamin A derivative that regulates various cellular processes, including cell growth, apoptosis, and differentiation.
Dysregulation of RARα signaling has been implicated in cancer, developmental disorders, and metabolic diseases, making it a promising target for therapeutic intervention.By using the Retinoic Acid Receptor Alpha Rabbit Monoclonal Antibody, researchers can gain insights into the role of RARα in various physiological and pathological processes, paving the way for potential therapeutic strategies targeting this important molecular pathway.
Product Name:
RARα Rabbit Monoclonal Antibody
SKU:
CAB19551
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RARα (P10276).
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Purification Method:
Affinity purification
Gene ID:
5914
Clone Number:
ARC0030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RARα Rabbit mAb (CAB19551) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.
