Ret Polyclonal Antibody (CAB0018)
- SKU:
- CAB0018
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | Ret Polyclonal Antibody |
SKU: | CAB0018 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Ret (NP_066124.1). |
Sequence: | DISK DLEK MMVK RRDY LDLA ASTP SDSL IYDD GLSE EETP LVDC NNAP LPRA LPST WIEN KLYG MSDP NWPG ESPV PLTR ADGT NTGF PRYP NDSV YANW M |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1; Ret |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 124kDa |
Observed MW: | 150kDa |
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Purification Method: | Affinity purification |
Gene ID: | 5979 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |