REST/NRSF Rabbit Polyclonal Antibody (CAB7161)
- SKU:
- CAB7161
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | REST/NRSF Rabbit Polyclonal Antibody |
SKU: | CAB7161 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-130 of human REST/NRSF (NP_005603.3). |
Sequence: | ALPN DMYD LHDL SKAE LAAP QLIM LANV ALTG EVNG SCCD YLVG EERQ MAEL MPVG DNNF SDSE EGEG LEES ADIK GEPH GLEN MELR SLEL SVVE PQPV FEAS GA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | WT6; XBR; HGF5; NRSF; DFNA27; GINGF5; REST/NRSF |
Positive Sample: | HeLa,Raji,SH-SY5Y,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 122kDa |
Observed MW: | 150kDa |
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.
Purification Method: | Affinity purification |
Gene ID: | 5978 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |