The REST Polyclonal Antibody (CAB2230) is a valuable tool for researchers studying the function of the RE1-silencing transcription factor (REST) in various biological processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the REST protein, this antibody enables accurate detection and analysis of REST expression in different cell types.REST is a transcriptional repressor that plays a crucial role in the regulation of gene expression, particularly in the nervous system where it is involved in neuronal differentiation and maintenance.
Dysregulation of REST has been linked to various neurodevelopmental and neurodegenerative disorders, making it a promising target for therapeutic interventions. By using the REST Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms regulated by REST, advancing our understanding of neurological diseases and potentially leading to the development of novel treatment strategies.
Product Name:
REST/NRSF Rabbit Polyclonal Antibody
SKU:
CAB2230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST/NRSF (NP_001180437.1).
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
5978
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of MCF-7 cells using REST/NRSF Rabbit pAb (CAB2230).Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution.
