REST/NRSF Rabbit Polyclonal Antibody (CAB2230)
- SKU:
- CAB2230
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | REST/NRSF Rabbit Polyclonal Antibody |
SKU: | CAB2230 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST/NRSF (NP_001180437.1). |
Sequence: | PVKI ELSP PIEV VQKE PVQM ELSP PMGV VQKE PAQR EPPP PREP PLHM EPIS KKPP LRKD KKEK SNMQ SERA RKEQ VLIE VGLV PVKD SWLL KESV STED LSPP SPPL PKEN LREE ASGD QKLL NTGE GNKE APLQ KVGA EEAD ESLP GLAA NINE STHI SSSG QNLN TPEG ETLN GKHQ TDSI VCEM KMDT DQNT RENL TGIN STVE EPVS PMLP PSAV EERE AVSK TALA SPPA TMAA NESQ EIDE DEGI HSHE GSDL SDNM SEGS DDSG LHGA RPVP QESS RKNA KEAL AVKA AKGD F |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | WT6; XBR; HGF5; NRSF; DFNA27; GINGF5; REST/NRSF |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 122kDa |
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.
Purification Method: | Affinity purification |
Gene ID: | 5978 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |