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REPS2 Antibody (PACO11802)

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SKU:
PACO11802
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€669

Description

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REPS2 Antibody (PACO11802)

The REP-2 Polyclonal Antibody (PAC011802) is a vital tool for researchers studying the REP-2 protein, which plays a crucial role in cellular processes. The antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the REP-2 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studies in cell biology and molecular biology.REP-2, also known as Rab escort protein 2, is involved in the transportation and localization of Rab GTPases, key regulators of vesicle trafficking. Its function in intracellular membrane trafficking makes it a key player in various cellular processes, including protein sorting and secretion.

Research on REP-2 is important for understanding fundamental cellular mechanisms and their implications in diseases like neurological disorders and cancer.By utilizing the REP-2 Polyclonal Antibody, researchers can delve deeper into the role of REP-2 in cellular processes and gain insights that may lead to potential therapeutic interventions targeting diseases associated with aberrant vesicle trafficking. Stay ahead in your research with this high-quality antibody specifically designed for studying the REP-2 protein.

Antibody Name:REPS2 Antibody (PACO11802)
Antibody SKU:PACO11802
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:
Species Reactivity:Human, Mouse
Immunogen:Human REPS2
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:RALBP1 associated Eps domain containing 2;REPS2;POB1 ;
UniProt Protein Function:REPS2: an adaptor protein involved in growth factor signaling through its influence on the Ral, a small G protein that regulates endocytosis of EGF and insulin receptors. Interacts with DDEF1, paxillin, RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. Forms a ternary complex with activated Ral and RALBP1. Binds epsin 1. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. EGF receptor internalization and signalling is inhibited by increased expression of REPS2. EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2. Two alternatively spliced isoforms have been described. Isoform 2 is down-regulated during progression of prostate cancer.
UniProt Protein Details:

Protein type:G protein regulator, misc.; Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp22.2

Molecular Function:protein binding

Biological Process: epidermal growth factor receptor signaling pathway; protein complex assembly

NCBI Summary:The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NFH8
NCBI GenInfo Identifier:34098575
NCBI Gene ID:9185
NCBI Accession:Q8NFH8.2
UniProt Secondary Accession:Q8NFH8,O43428, Q5JNZ8, Q8NFI5, A6PWZ6,
UniProt Related Accession:Q8NFH8
Molecular Weight:71,405 Da
NCBI Full Name:RalBP1-associated Eps domain-containing protein 2
NCBI Synonym Full Names:RALBP1 associated Eps domain containing 2
NCBI Official Symbol:REPS2  
NCBI Official Synonym Symbols:POB1  
NCBI Protein Information:ralBP1-associated Eps domain-containing protein 2
UniProt Protein Name:RalBP1-associated Eps domain-containing protein 2
UniProt Synonym Protein Names:Partner of RalBP1; RalBP1-interacting protein 2
Protein Family:RalBP1-associated Eps domain-containing protein
UniProt Gene Name:REPS2  
UniProt Entry Name:REPS2_HUMAN

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