UPF1/RENT1 Rabbit Monoclonal Antibody (CAB5071)
- SKU:
- CAB5071
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | UPF1/RENT1 Rabbit Monoclonal Antibody |
SKU: | CAB5071 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UPF1/RENT1 (Q92900). |
Sequence: | MSVE AYGP SSQT LTFL DTEE AELL GADT QGSE FEFT DFTL PSQT QTPP GGPG GPGG GGAG GPGG AGAG AAAG QLDA QVGP EGIL QNGA VDDS VAKT SQLL |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | UTF; HUPF1; NORF1; RENT1; smg-2; pNORF1; UPF1/RENT1 |
Positive Sample: | HeLa,C2C12,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, P-body. |
Calculated MW: | 124kDa |
Observed MW: | 140kDa |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5976 |
Clone Number: | ARC1268 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |