The Renin Rabbit Monoclonal Antibody (CAB5197) is a cutting-edge tool for research involving renin, an essential enzyme involved in the regulation of blood pressure and fluid balance. This highly reactive antibody, raised in rabbits, is specifically designed for use with human samples and has been validated for Western blot applications.Renin is a key player in the renin-angiotensin-aldosterone system, which regulates blood pressure and electrolyte balance in the body. Dysregulation of this system can lead to conditions such as hypertension and cardiovascular disease, making renin a crucial target for research in the fields of cardiology and nephrology.This monoclonal antibody binds specifically to renin, allowing for accurate detection and analysis in various cell types.
Its high specificity and sensitivity make it an ideal tool for studying renin expression and activity in both normal physiology and disease states.Researchers in the fields of cardiology, nephrology, and endocrinology will find this antibody invaluable for their studies on renin and its role in maintaining cardiovascular and renal health. By gaining a better understanding of renin function, researchers can uncover new insights into the pathogenesis of cardiovascular and renal diseases, potentially leading to the development of novel therapeutic strategies.
Product Name:
Renin Rabbit Monoclonal Antibody
SKU:
CAB5197
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Renin (P00797).
This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
Purification Method:
Affinity purification
Gene ID:
5972
Clone Number:
ARC1149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Renin Rabbit mAb (CAB5197) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
