The Renin Polyclonal Antibody (CAB1585) is a valuable tool for researchers studying renin, an enzyme involved in the regulation of the renin-angiotensin system and blood pressure. This antibody, produced in rabbits, has a high specificity for human samples and has been validated for use in Western blot applications.Renin is a key component in the renin-angiotensin system, which plays a critical role in regulating blood pressure and electrolyte balance. Dysregulation of this system has been implicated in various cardiovascular diseases, making renin a potential target for therapeutic interventions.
The Renin Polyclonal Antibody enables researchers to detect and quantify renin levels in different cell types, providing valuable insights into its role in health and disease.By studying renin and its functions, researchers can gain a better understanding of the mechanisms underlying hypertension and other cardiovascular disorders. This antibody is a valuable tool for investigating the potential therapeutic applications of targeting renin in the treatment of these conditions.
Product Name:
Renin Rabbit Polyclonal Antibody
SKU:
CAB1585
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-406 of human Renin (NP_000528.1).
This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
Purification Method:
Affinity purification
Gene ID:
5972
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Renin antibody (CAB1585) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
