The RELN Polyclonal Antibody (CAB17936) is a versatile tool for researchers studying the function of the RELN protein in various biological processes. This antibody, generated in rabbits, is highly specific and sensitive to RELN, a protein involved in neuronal migration and positioning during brain development.With its reactivity towards human samples, the RELN Polyclonal Antibody is suitable for Western blot applications, allowing for accurate detection and quantification of RELN expression levels in different cell types.
Its specificity ensures reliable results, making it an excellent choice for studies on neurodevelopmental disorders, such as autism and schizophrenia.The RELN Polyclonal Antibody provides researchers with a valuable tool to investigate the role of RELN in brain development and neurological disorders. By targeting RELN, this antibody opens up opportunities for deeper insights into the molecular mechanisms underlying these conditions, laying the foundation for potential therapeutic advancements in the future.
Product Name:
RELN Rabbit Polyclonal Antibody
SKU:
CAB17936
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-190 of human RELN (NP_005036.2).
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
Purification Method:
Affinity purification
Gene ID:
5649
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RELN Rabbit pAb (CAB17936) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
