The RELA Polyclonal Antibody (CAB22684) is specifically designed for research involving RELA, a protein related to immune regulation and inflammation. This antibody, generated in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of RELA in various cell types.RELA, also known as NF-kappa-B p65 subunit, plays a crucial role in regulating the immune response and inflammatory processes. Its involvement in these pathways makes it a key molecule to study in the context of diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By understanding the function of RELA, researchers can develop targeted therapies that manipulate immune responses for therapeutic benefit.Overall, the RELA Polyclonal Antibody (CAB22684) is a valuable tool for researchers in the fields of immunology and cancer research, offering insight into the role of RELA in immune system regulation and disease pathogenesis.
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit).
Purification Method:
Affinity purification
Gene ID:
19697
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type(WT) and RELA knockout (KO) HeLa cells, using RELA Rabbit pAb antibody (CAB22684) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
