The REL Polyclonal Antibody (CAB1181) is a specialized research tool designed for investigating the protein REL, a key regulator of immune response and cell survival. Produced in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the REL protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it suitable for studies in immunology and cancer research.REL, also known as c-Rel, is a transcription factor that plays a vital role in controlling gene expression related to inflammation, cell proliferation, and apoptosis.
Dysregulation of REL signaling has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Research into the function of REL is essential for developing targeted therapies that can modulate immune responses and potentially treat these health issues.In summary, the REL Polyclonal Antibody (CAB1181) is a valuable tool for scientists investigating the role of REL in immune regulation and disease pathology. Its high reactivity and specificity make it a reliable choice for Western blot experiments, providing crucial insights into the molecular mechanisms underlying immune response modulation.
Product Name:
REL Rabbit Polyclonal Antibody
SKU:
CAB1181
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human REL (NP_002899.1).
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5966
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using REL antibody (CAB1181) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
