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REG3G Antibody (PACO36898)

SKU:
PACO36898
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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REG3G Antibody (PACO36898)

The REG3G Antibody (PAC036898) is a polyclonal antibody designed for research involving REG3G, a protein that plays a critical role in immune regulation and inflammation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. REG3G is a member of the Regenerating islet-derived (REG) family of proteins, which are involved in various biological processes including cell proliferation, differentiation, and immune response regulation. REG3G has been implicated in promoting tissue repair and modulating immune responses in the intestine, and its dysregulation is associated with inflammatory conditions and cancer.

This antibody specifically binds to REG3G, allowing for the detection and analysis of REG3G levels in different cell types, making it a valuable tool for researchers studying immunology, gastrointestinal diseases, and cancer. Understanding the role of REG3G in immune regulation and inflammation may provide insights into potential therapeutic targets for treating inflammatory disorders and cancer.

Antibody Name:REG3G Antibody (PACO36898)
Antibody SKU:PACO36898
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Regenerating islet-derived protein 3-γ protein (27-175AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.
Synonyms:Regenerating islet-derived protein 3-γ (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-γ 16.5 kDa form; Regenerating islet-derived protein 3-γ 15 kDa form], REG3G, PAP1B
UniProt Protein Function:REG3G: Might be a stress protein involved in the control of bacterial proliferation.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: cytoplasm; extracellular region

Molecular Function:peptidoglycan binding

Biological Process: acute-phase response; antimicrobial humoral response; cytolysis in other organism; defense response to Gram-positive bacterium; MyD88-dependent toll-like receptor signaling pathway; negative regulation of keratinocyte differentiation

NCBI Summary:This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
UniProt Code:Q6UW15
NCBI GenInfo Identifier:56699413
NCBI Gene ID:130120
NCBI Accession:NP_001008388.1
UniProt Secondary Accession:Q6UW15,Q3SYE4, Q3SYE6, Q6FH18, A8K980, D6W5J6,
UniProt Related Accession:Q6UW15
Molecular Weight:
NCBI Full Name:regenerating islet-derived protein 3-gamma isoform 1 preproprotein
NCBI Synonym Full Names:regenerating family member 3 gamma
NCBI Official Symbol:REG3G  
NCBI Official Synonym Symbols:PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III  
NCBI Protein Information:regenerating islet-derived protein 3-gamma
UniProt Protein Name:Regenerating islet-derived protein 3-gamma
UniProt Synonym Protein Names:Pancreatitis-associated protein 1B; PAP-1B
Protein Family:Regenerating islet-derived protein
UniProt Gene Name:REG3G  

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