The RecQL4 Polyclonal Antibody (CAB6846) is a valuable tool for researchers studying RecQL4, a protein involved in DNA repair and maintenance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the RecQL4 protein, it enables researchers to detect and analyze RecQL4 expression in a variety of cell types, making it particularly useful for studies in genetics, oncology, and aging research.RecQL4 is a member of the RecQ helicase family known for its role in maintaining genomic stability by resolving DNA damage and preventing mutations.
Dysregulation of RecQL4 has been implicated in various genetic disorders, cancer, and premature aging syndromes. Investigating the function of RecQL4 with the help of this antibody is essential for gaining insights into the mechanisms of DNA repair and potentially identifying new therapeutic targets for these diseases.Overall, the RecQL4 Polyclonal Antibody (CAB6846) serves as a valuable tool for researchers seeking to unravel the complex roles of RecQL4 in cellular processes and disease pathways. Its high specificity and sensitivity make it an ideal choice for advancing studies in DNA repair mechanisms and genetic diseases.
Product Name:
RECQL4 Rabbit Polyclonal Antibody
SKU:
CAB6846
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 231-330 of human RECQL4 (NP_004251.3).
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes.
Purification Method:
Affinity purification
Gene ID:
9401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RECQL4 antibody (CAB6846) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
