recQ Antibody (PACO33884)
- SKU:
- PACO33884
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Escherichia coli
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
recQ Antibody (PACO33884)
The RecQ Antibody (PAC033884) is a polyclonal antibody specifically designed for research involving RecQ, a family of DNA helicases essential for maintaining genome stability. This antibody, produced through immunization of rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds specifically to the RecQ protein, enabling accurate detection and analysis in a variety of cell types, making it an invaluable tool for studies in genetics and cancer research.
The RecQ protein family plays a vital role in DNA repair and recombination processes, making it an important target for research in understanding the mechanisms of genome maintenance and stability. Mutations in RecQ genes have been associated with various genetic disorders, including Bloom syndrome and Werner syndrome. Understanding the function and regulation of RecQ proteins is essential for developing potential therapies for these diseases and for advancing our knowledge of DNA repair mechanisms.
| Antibody Name: | recQ Antibody (PACO33884) |
| Antibody SKU: | PACO33884 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Escherichia coli |
| Immunogen: | Recombinant Escherichia coli ATP-dependent DNA helicase RecQ protein (2-606AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: ATP-dependent DNA helicase RecQ antibody at 2µg/ml + DH5a whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 68 kDa Observed band size: 68 kDa . |
| Background: | Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase. |
| Synonyms: | ATP-dependent DNA helicase RecQ (EC 3.6.4.12), recQ |
| UniProt Protein Function: | Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase. |
| UniProt Protein Details: | |
| NCBI Summary: | SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). [More information is available at EcoGene: EG10833]. A component of the RecF recombinational pathway, RecQ is a helicase that functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks. [More information is available at EcoCyc: EG10833]. |
| UniProt Code: | P15043 |
| NCBI GenInfo Identifier: | 445957726 |
| NCBI Gene ID: | 948318 |
| NCBI Accession: | WP_000035581.1 |
| UniProt Secondary Accession: | P15043,P76762, Q2M8C7, Q6BEZ3 |
| UniProt Related Accession: | P15043 |
| Molecular Weight: | 71.9 kDa |
| NCBI Full Name: | MULTISPECIES: ATP-dependent DNA helicase RecQ |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | recQÂ Â |
| NCBI Official Synonym Symbols: | ECK3816; JW5855Â Â |
| NCBI Protein Information: | ATP-dependent DNA helicase |
| UniProt Protein Name: | ATP-dependent DNA helicase RecQ |
| UniProt Synonym Protein Names: | |
| Protein Family: | ATP-dependent DNA helicase |
| UniProt Gene Name: | recQÂ Â |
| UniProt Entry Name: | RECQ_ECOLI |
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