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Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc) (RPES6792)

SKU:
RPES6792
Product Type:
Recombinant Protein
Species:
Monkey
€279

Description

Product Name:Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc)
Product Code:RPES6792
Size:10µg
Species:Rhesus Macaque
Expression Host:HEK293 Cells
Synonyms:Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2
Mol Mass:110.6 kDa
AP Mol Mass:120-140 kDa
Tag:C-Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Immobilized 2019-nCoV S Protein RBD-SD1-mFcat 2μg/ml (100 μl/well) can bind Rhesus Macaque ACE-2-Fc. The ED50 of Recombinant Rhesus Macaque ACE-2-Hisis 96 ng/ml.
Sequence:Gln18-Val739
Accession:ACI04564.1
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation:Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Not Applicable
Background:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

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