Recombinant Rat MCP-1 Protein (Sumo Tag) (RPES8229)
- SKU:
- RPES8229
- Size:
- 20μg
- Tag:
- N-Sumo
- Reactivity:
- Rat
- Expression Host:
- E.coli
- Accession:
- P14844
Frequently bought together:
Description
| Product Name: | Recombinant Rat MCP-1 Protein (Sumo Tag) |
| SKU: | RPES8229 |
| Size: | 20μg |
| Tag: | N-Sumo |
| Reactivity: | Rat |
| Expression Host: | E.coli |
| Accession: | P14844 |
| Sequence: | Gln24-Asn148 |
| Calculated Molecular Weight: | 26.6 kDa |
| Observed Molecular Weight: | 35 kDa |
| Synonyms: | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP1, SCYA2, SMC-CF, |
| Endotoxin: | < 10 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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