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Rat HER2/ErbB2 Recombinant Protein (RPES2568)

SKU:
RPES2568
Product Type:
Recombinant Protein
Species:
Rat
Research Area:
Epigenetics & Nuclear Signaling
€221
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Description

system_update_altDatasheet

Rat HER2/ErbB2 Recombinant Protein

ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.

Product Name:Rat HER2/ErbB2 Recombinant Protein (RPES2568)
Product Code:RPES2568
Size:10µg
Species:Rat
Expressed Host:E.coli
Synonyms:Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, ERBB2,ENV,ENVW,ERVWE1,HER-2,HER-2/neu,HER2,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV,MLN 19,MLN19
Accession:P06494
Sequence:Ala67-Val323
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by LAL test.
Protein Construction:Recombinant Rat Receptor tyrosine-protein kinase ErbB-2 is produced by our E.coli expression system and the target gene encoding Ala67-Val323 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by SDS-PAGE
Mol Mass:29.3 kDa
AP Mol Mass:32 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM Tris,150mM NaCl, 4M Urea, pH 8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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