Recombinant Rat CCL5/RANTES Protein (RPCB0720)
- SKU:
- RPCB0720
- Size:
- 10µg
- Tag:
- N-6×His
- Reactivity:
- Rat
Description
| Product Name: | Recombinant Rat CCL5/RANTES Protein |
| SKU: | RPCB0720 |
| Size: | 10µg |
| Tag: | N-6×His |
| Reactivity: | Rat |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Rat CCL5/RANTES Protein , tested reactivity inE. coliand has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 1 EU/μg of the protein by LAL method. |
| Purity: | > 95% by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH7.4.Contact us for customized product form or formulation. |
| Gene ID: | 81780 |
C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune responseby means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatorysites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatoryresponses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerizationof CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well asCCL5 ’ s interaction with the chemokine CXCL4/PF4.The deposition of CCL5 on activated vascular endothelialcells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for theextravasation of adherent leukocytes.CCL5 is upregulated in breast cancer and promotes tumor progressionthrough the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells,and the vasculature.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
| Swiss-Prot: | P50231 |
 | Recombinant Rat CCL5/RANTES Protein was determined by SDS- PAGE under reducing conditions with Coomassie Blue. showing a band at 5-14 kDa. |
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