It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
Product Name:
Mouse LTBR/TNFRSF3 Recombinant Protein (RPES2192)
Product Code:
RPES2192
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Tumor necrosis factor receptor superfamily member 3,Lymphotoxin-beta receptor,Ltbr,Tnfcr,Tnfrsf3
Accession:
P50284
Sequence:
Ser28-Pro218
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Lymphotoxin beta Receptor is produced by our Mammalian expression system and the target gene encoding Ser28-Pro218 is expressed with a Fc tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
48.7 kDa
AP Mol Mass:
61kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
