IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Product Name:
Mouse Interleukin7/IL7 Recombinant Protein (RPES4576)
Product Code:
RPES4576
Size:
20µg
Species:
Mouse
Expressed Host:
E.coli
Synonyms:
Ctla-8,Ctla8,IL-17,IL-17A,Il17
Accession:
Q62386
Sequence:
Thr 22-Ala158
Activity:
1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant mouse IL17a at 10 µg/mL (100 ?l/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng/mL.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.
Purity:
> 97 % as determined by SDS-PAGE
Mol Mass:
15.5 kDa
AP Mol Mass:
16 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
