ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor ? chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-?B (NF-?B) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.
Product Name:
Mouse IL1RL1/ST2 Recombinant Protein (RPES1227)
Product Code:
RPES1227
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Interleukin-1 receptor-like 1, Lymphocyte antigen 84, Protein ST2, Protein T1, Il1rl1, DER4, Fit-1, IL-1 R4, IL-1RL1, IL-33R, Ly84, ST2L, ST2V, suppression of tumorigenicity 2
Accession:
P14719-2
Sequence:
Ser27-Ala337
Fusion tag:
C-Fc
Activity:
Immobilized Mouse IL-33(Cat: PKSM041090) at 5µg/ml(100 ?l/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 5ug/ml .
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Interleukin-1 receptor-like 1 is produced by our Mammalian expression system and the target gene encoding Ser27-Ala337 is expressed with a Fc tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
62.7 kDa
AP Mol Mass:
90-110 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
