Recombinant Mouse IL-17 RB Protein (His Tag) (RPES8499)
- SKU:
- RPES8499
- Size:
- 20μg
- Tag:
- C-His
- Reactivity:
- Mouse
- Expression Host:
- Mammalian
- Accession:
- Q9JIP3
Description
| Product Name: | Recombinant Mouse IL-17 RB Protein (His Tag) |
| SKU: | RPES8499 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Mouse |
| Expression Host: | Mammalian |
| Accession: | Q9JIP3 |
| Sequence: | Arg18-Gly286 |
| Calculated Molecular Weight: | 29.5 kDa |
| Observed Molecular Weight: | 41 kDa |
| Synonyms: | Evi, IL17RH, IL-17Rh, IL-17ER, IL17RH1, IL-17Rh1, Evi27, Il17br, Il17rb |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-, prepro B cells, fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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