Recombinant Mouse IL-11 Protein (Trx Tag) (RPES8215)
- SKU:
- RPES8215
- Size:
- 20μg
- Tag:
- N-Trx
- Reactivity:
- Mouse
- Expression Host:
- E.coli
- Accession:
- P47873
Description
| Product Name: | Recombinant Mouse IL-11 Protein (Trx Tag) |
| SKU: | RPES8215 |
| Size: | 20μg |
| Tag: | N-Trx |
| Reactivity: | Mouse |
| Expression Host: | E.coli |
| Accession: | P47873 |
| Sequence: | Pro22-Leu199 |
| Calculated Molecular Weight: | 39.4 kDa |
| Observed Molecular Weight: | 45 kDa |
| Synonyms: | Interleukin, IL-11, Interleukin-11, Zcyto1, Zcyto10, Il11, AGIF, interleukin 11 |
| Endotoxin: | < 10 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha, such functions include placentation and to some extent of decidualization.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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