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Recombinant Mouse ICAM-1/CD54 Protein (Fc Tag) (RPES8492)

SKU:
RPES8492
Size:
20μg
Tag:
C-Fc
Reactivity:
Mouse
Expression Host:
Mammalian
Accession:
P13597
$347
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Description

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Product Name:Recombinant Mouse ICAM-1/CD54 Protein (Fc Tag)
SKU:RPES8492
Size:20μg
Tag:C-Fc
Reactivity:Mouse
Expression Host:Mammalian
Accession:P13597
Sequence:Gln28-Asn485
Calculated Molecular Weight:75.2 kDa
Observed Molecular Weight:90 kDa
Synonyms:MyD, P3., MALA, ICAM-1/CD, MAL, CD54, Icam, Ly-4, Ly-47, Icam-1, MALA-2, BB2, ICAM-1/CD54, Intercellular adhesion molecule 1, MyD10, P3.58, Icam1, Ly-47, MALA-2, CD54, Icam, Icam-1, Ly-4
Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method
Purity:> 90% as determined by reducing SDS-PAGE.

Intercellular adhesion molecule-1 (ICAM-1 , or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells , but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally , ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated , leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics , ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of Human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE) , providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

Bio-activity:Not validated for activity
Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

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