Recombinant Mouse gp130 Protein (Fc Tag) (RPES8507)
- SKU:
- RPES8507
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Mouse
- Expression Host:
- Mammalian
- Accession:
- Q00560
Description
| Product Name: | Recombinant Mouse gp130 Protein (Fc Tag) |
| SKU: | RPES8507 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Mouse |
| Expression Host: | Mammalian |
| Accession: | Q00560 |
| Sequence: | Gln23-Glu617 |
| Calculated Molecular Weight: | 90.3 kDa |
| Observed Molecular Weight: | 90-100 kDa |
| Synonyms: | CDW, CD130, CDW130, IL-6RB, Interleukin 6 signal transducer, IR6RB, Il6st, 5133400A03Rik, AA389424, BB405851, D13Ertd699e, gp130 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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