Description
Product Name: | Recombinant Mouse GITR/TNFRSF18 Protein (Fc Tag) |
SKU: | RPES8506 |
Size: | 20μg |
Tag: | C-Fc |
Reactivity: | Mouse |
Expression Host: | Mammalian |
Accession: | O35714 |
Sequence: | Gln20-His153 |
Calculated Molecular Weight: | 39.6 kDa |
Observed Molecular Weight: | 50 kDa |
Synonyms: | Tumor necrosis factor receptor superfamily member, Tnfrsf, AITR, CD357, GITR-D, Glucocorticoid-induced TNFR-related protein, Tumor necrosis factor receptor superfamily member 18, Gitr, Tnfrsf18, GITR, AITR |
Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
Purity: | > 90% as determined by reducing SDS-PAGE. |
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
Bio-activity: | Not validated for activity |
Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |