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Mouse GITR/TNFRSF18 Recombinant Protein (RPES0865)

SKU:
RPES0865
Product Type:
Recombinant Protein
Species:
Mouse
€212
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Description

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Mouse GITR/TNFRSF18 Recombinant Protein

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Product Name:Mouse GITR/TNFRSF18 Recombinant Protein (RPES0865)
Product Code:RPES0865
Size:10µg
Species:Mouse
Expressed Host:Human Cells
Synonyms:Tumor necrosis factor receptor superfamily member 18,Glucocorticoid-induced TNFR-related protein,Tnfrsf18, AITR,CD357,GITR-D,TNFRSF18
Accession:O35714
Sequence:Ser22-His153
Fusion tag:C-Fc-6His
Activity:Immobilized Human GITRL-His(Cat: PKSH032485) at 10µg/ml(100 ?l/well) can bind Mouse GITR -Fc-His.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a Fc, 6His tag at the C-terminus.
Purity:> 90 % as determined by SDS-PAGE
Mol Mass:41.12 kDa
AP Mol Mass:60kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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