Mouse Frizzled 2/FZD2 Recombinant Protein (RPES0846)
- SKU:
- RPES0846
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Frequently bought together:
Description
system_update_altDatasheet
Mouse Frizzled 2/FZD2 Recombinant Protein
Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.
| Product Name: | Mouse Frizzled 2/FZD2 Recombinant Protein (RPES0846) |
| Product Code: | RPES0846 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Frizzled-2, Fz-2, mFz2, Fzd2,frizzled (Drosophila) homolog 2 |
| Accession: | Q9JIP6 |
| Sequence: | Gln29-Leu168 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse frizzled (Drosophila) homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 42.9 kDa |
| AP Mol Mass: | 55-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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