Recombinant Mouse FLT-3/FLK-2/CD135 Protein (RPCB1849)
- SKU:
- RPCB1849
- Size:
- 10µg
- Tag:
- C-hFC
- Reactivity:
- Mouse
- Expression Host:
- HEK293 cells
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Description
| Product Name: | Recombinant Mouse FLT-3/FLK-2/CD135 Protein |
| SKU: | RPCB1849 |
| Size: | 10µg |
| Tag: | C-hFC |
| Reactivity: | Mouse |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Mouse FLT-3/FLK-2/CD135 Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 0.01 EU/μg |
| Purity: | > 95% as determined by HPLC |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
| Gene ID: | 14255 |
This protein is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | Q00342 |
 | Recombinant Mouse FLT-3/FLK-2 Protein was determined by SDS- PAGE with Coomassie Blue, showing a band at 100-140 kDa. |
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