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Recombinant Mouse FGCP/GCPII/mGCP/NAALADase I/PSMA(N-6His) (RPES6657)

SKU:
RPES6657
Product Type:
Recombinant Protein
Species:
Mouse
$239

Description

Product Name:Recombinant Mouse FGCP/GCPII/mGCP/NAALADase I/PSMA(N-6His)
Product Code:RPES6657
Size:10µg
Species:Mouse
Expression Host:HEK293 Cells
Synonyms:Glutamate carboxypeptidase 2, FGCP, GCPII, mGCP, NAALADase I, PSMA, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1
Mol Mass:80.7 kDa
AP Mol Mass:100-120 kDa
Tag:N-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Testing in progress
Sequence:Ile44-Ala752
Accession:Q0VDM5
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.

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