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Mouse FAS/TNFRSF6 Recombinant Protein (RPES2135)

SKU:
RPES2135
Product Type:
Recombinant Protein
Species:
Mouse
Research Area:
Cell Death
€221
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Description

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Mouse FAS/TNFRSF6 Recombinant Protein

Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Product Name:Mouse FAS/TNFRSF6 Recombinant Protein (RPES2135)
Product Code:RPES2135
Size:10µg
Species:Mouse
Expressed Host:Human Cells
Synonyms:Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor,CD95,Fas,TNFRSF6
Accession:P25446
Sequence:Gln22-Arg169
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse FAS is produced by our Mammalian expression system and the target gene encoding Gln22-Arg169 is expressed with a Fc tag at the C-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:43.7 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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