Recombinant Mouse CXCL2/MIP-2 Protein (Sumo Tag) (RPES8192)
- SKU:
- RPES8192
- Size:
- 20μg
- Tag:
- N-Sumo
- Reactivity:
- Mouse
- Expression Host:
- E.coli
- Accession:
- P10889
Description
| Product Name: | Recombinant Mouse CXCL2/MIP-2 Protein (Sumo Tag) |
| SKU: | RPES8192 |
| Size: | 20μg |
| Tag: | N-Sumo |
| Reactivity: | Mouse |
| Expression Host: | E.coli |
| Accession: | P10889 |
| Sequence: | Ala28-Asn100 |
| Calculated Molecular Weight: | 20.9 kDa |
| Observed Molecular Weight: | 27 kDa |
| Synonyms: | GRO, chemokine ligand, Scyb, C-X-C motif chemokine, CXCL, chemokine ligand 2, CINC2a, CINC-2a, C-X-C motif chemokine 2, GRO beta, GRO2, GRO2 oncogene|MGSA beta|melanoma growth stimulatory activity beta, GROB, Gro-beta, Growth-regulated protein beta, Macrophage Inflammatory Protein-2-alpha, melanoma growth stimulatory activity beta, MGSA-b, MGSA-beta, MIP2A, MIP-2a, MIP2-alpha, SCYB2., Mip-2, Mip2, Scyb2, Cxcl2 |
| Endotoxin: | < 10 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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