Recombinant Mouse CTLA-4/CD152 Protein (Fc Tag) (RPES8401)
- SKU:
- RPES8401
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Mouse
- Expression Host:
- Mammalian
- Accession:
- P09793
Description
| Product Name: | Recombinant Mouse CTLA-4/CD152 Protein (Fc Tag) |
| SKU: | RPES8401 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Mouse |
| Expression Host: | Mammalian |
| Accession: | P09793 |
| Sequence: | Glu36-Asp161 |
| Calculated Molecular Weight: | 38.8 kDa |
| Observed Molecular Weight: | 45-55 kDa |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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