The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.
Product Name:
Mouse CD209B/DC-SIGNR1 Recombinant Protein (RPES1818)
Product Code:
RPES1818
Size:
50µg
Species:
Mouse
Expressed Host:
HEK293 Cells
Synonyms:
1810030I22Rik,DC-SIGNR1,mSIGNR1,OtB7,SIGNR1
Accession:
NP_081248.2
Sequence:
Gln 74-Gly 325
Fusion tag:
N-His
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of mouse CD209B isoform 1 (NP_081248.2) (Gln 74-Gly 325) was fused with a polyhistidine tag at the N-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
31.4 kDa
AP Mol Mass:
40 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
