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Mouse CD122/IL-2RB Recombinant Protein (RPES4483)

SKU:
RPES4483
Product Type:
Recombinant Protein
Species:
Mouse
€1,190
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Description

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Mouse CD122/IL-2RB Recombinant Protein

Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.

Product Name:Mouse CD122/IL-2RB Recombinant Protein (RPES4483)
Product Code:RPES4483
Size:5µg
Species:Mouse
Expressed Host:HEK293 Cells
Synonyms:CD122,IL-15Rbeta,Il-2/15Rbeta,Il-2Rbeta,IL15Rbeta,p70
Accession:P16297
Sequence:Met1-Glu240
Fusion tag:C-His
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the mouse IL2RB (P16297) (Met1-Glu240) was expressed with a C-terminal polyhistidine tag.
Purity:> 90 % as determined by SDS-PAGE
Mol Mass:26.5 kDa
AP Mol Mass:45-54 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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