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Recombinant Mouse AXL/UFO Protein ( Fc Tag) (RPES8450)

SKU:
RPES8450
Size:
20μg
Tag:
C-Fc
Reactivity:
Mouse
Expression Host:
Mammalian
Accession:
Q00993
€289
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Description

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Product Name:Recombinant Mouse AXL/UFO Protein ( Fc Tag)
SKU:RPES8450
Size:20μg
Tag:C-Fc
Reactivity:Mouse
Expression Host:Mammalian
Accession:Q00993
Sequence:Ala19A-Trp445
Calculated Molecular Weight:71.8 kDa
Observed Molecular Weight:90-110 kDa
Synonyms:Adhesion related kinase, AI323647, Ark, Axl, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming gene, AXL transforming sequence/gene, EC 2.7.10.1, JTK11, Oncogene AXL, Tyro7, Tyrosine protein kinase receptor UFO, Tyrosine-protein kinase receptor UFO, UFO, UFO
Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method
Purity:> 90% as determined by reducing SDS-PAGE.

Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Bio-activity:Not validated for activity
Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

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