Tyrosinase-related protein 1; also known as TYRP1 or TRP1; is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5;6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5;6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis; TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.
Product Name:
Human TRP1/TYRP1 Recombinant Protein (RPES0636)
Product Code:
RPES0636
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
b-PROTEIN,CAS2,CATB,GP75,OCA3,TRP,TRP1,TYRP
Accession:
P17643
Sequence:
Met 1- Arg 471
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
52.2 kDa
AP Mol Mass:
66 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
