Recombinant human Trk-A/NTRK1 Protein (RPCB1522)
- SKU:
- RPCB1522
- Size:
- 10µg
- Tag:
- C-6His
- Reactivity:
- human
- Expression Host:
- HEK293 cells
Description
| Product Name: | Recombinant human Trk-A/NTRK1 Protein |
| SKU: | RPCB1522 |
| Size: | 10µg |
| Tag: | C-6His |
| Reactivity: | human |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant human Trk-A/NTRK1 Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 0.01EU/μg |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
| Gene ID: | 4914 |
This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | P04629-1 |
 | Recombinant human Trk-A/NTRK1 Protein was determined by SDS- PAGE with Coomassie Blue, showing a band at 75-90kDa. |
 | Recombinant human Trk-A/NTRK1 inhibit NGF-induced proliferation of TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is 0.086-0.34 µg/mL in the presence of 10 ng/mL of Recombinant Human beta-NGF. |
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