The STC2/Stanniocalcin-2 protein is a secreted heterodimeric glycoprotein that is present in many tissues and may have autocrine or paracrine actions. Casein kinase 2 phosphorylates STC2 solely on its serine residues, with ten of the protein's 15 cysteine residues shared by other members of the stanniocalcin family. STC2 plays a role in the regulation of calcium and phosphate transport in the kidneys and intestines as well as cell metabolism and cellular calcium/phosphate homeostasis. Mice with constitutive overexpression of human stanniocalcin 2 displayed prenatal and postnatal growth restriction, reduced bone and muscular protein development, and organomegaly. Estrogen activates the production of this gene, which is increased in some breast cancers. STC2 is associated with renal cell carcinoma and nonpapillary renal cell carcinoma. Human STC2/Stanniocalcin 2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human STC2/Stanniocalcin 2 Recombinant Protein (RPES4367)
Product Code:
RPES4367
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
STC-2,STCRP
Accession:
O76061
Sequence:
Met 1-Arg302
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human STC2 (O76061) (Met1-Arg302) was expressed with a C-terminal polyhistidine tag.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
32.1 kDa
AP Mol Mass:
35-42 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
