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Human SRC Kinase/c-SRC Recombinant Protein (RPES1553)

SKU:
RPES1553
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
€805
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Description

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Human SRC Kinase/c-SRC Recombinant Protein

Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.

Product Name:Human SRC Kinase/c-SRC Recombinant Protein (RPES1553)
Product Code:RPES1553
Size:20µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:ASV,c-SRC,p60-Src,SRC1
Accession:P12931-1
Sequence:Met 1-Leu 536
Fusion tag:N-His & GST
Activity:The specific activity was determined to be ?80 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human SRC (P12931-1) (Met 1-Leu 536) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:87.7 kDa
AP Mol Mass:81 kDa
Formulation:Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 20% gly, 0.3mM DTT
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

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