alpha-2-macroglobulin, also known as alpha;2-macroglobulin (alpha;2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. The major protein component of the alpha-2 band in protein electrophoresis is alpha-2-macroglobulin, which is generated by the liver. A major plasma glycoprotein, alpha-2-macroglobulin has long been recognized as an irreversible proteinase inhibitor. It has been confirmed that a variety of growth factors, cytokines, and hormones bind to alpha 2M in various ways. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. A2M has been found in the brains of Alzheimer's disease (AD) patients, where it is distributed throughout amyloid plaques. A2M binds soluble beta-amyloid and mediates its degradation. Because alpha2-macroglobulin and its protease cargo are selectively bound by cells in contact with the body fluids, they are then internalized and destroyed in secondary lysosomes of those cells. Alpha2-macroglobulin binds a variety of ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods. Human Serum Albumin/HSA Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Serum Albumin/HSA Recombinant Protein (RPES4796)
Product Code:
RPES4796
Size:
200µg
Species:
Human
Expressed Host:
Yeast
Synonyms:
Serum Albumin, HAS, ALB
Accession:
NP_000468.1
Sequence:
Met 1-Leu609, Ala215Val,natrual variant
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding human HSA (NP_000468.1)(Met1-Leu609, Ala215Val,natrual variant) was expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
66.5 kDa
AP Mol Mass:
58-67 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
