Recombinant Human Serpin F2/Alpha-2-antiplasmin Protein (RPCB0237)
- SKU:
- RPCB0237
- Size:
- 50µg
- Tag:
- C-His
- Reactivity:
- Human
- Expression Host:
- HEK293 cells
Description
| Product Name: | Recombinant Human Serpin F2/Alpha-2-antiplasmin Protein |
| SKU: | RPCB0237 |
| Size: | 50µg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human Serpin F2/Alpha-2-antiplasmin Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 0.1 EU/μg of the protein by LAL method. |
| Purity: | > 90% by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| Gene ID: | 5345 |
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, Serpin F2 is also an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta also express this protein at a moderate level.SerpinF2 is one of the inhibitors of fibrinolysis. It is a specific plasmin inhibitor, which degrades fibrin and various other proteins. Consequently, the protein plays the dominant role in regulating the blood clotting pathway. Mutations in SerpinF2 gene lead to alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | P08697 |
 | Recombinant Human Serpin F2/Alpha-2-antiplasmin Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 70 kDa. |
 | Recombinant human SERPINF2 inhibits trypsin cleavage of a fluorogenic peptide substrate, Mca- RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <0.23nM. |
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