S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins; and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer; and is normally present in cells derived from the neural crest; chondrocytes; macrophages; dendritic cells; etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation; transcription factors; the dynamics of cytoskeleton constituents; enzyme activities; cell growth and differentiation; and the inflammatory response. S100A6 (S100 calcium binding protein A6) is a member of the S100 family of proteins; and functions in prolactin secretion; and exocytosis. Chromosomal rearrangements and altered expression of S100A6 have been implicated in melanoma.
Product Name:
Human S100A6 Recombinant Protein (RPES5000)
Product Code:
RPES5000
Size:
20µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
S100A6,Protein S100-A6,Calcyclin,Growth factor-inducible protein 2A9,MLN 4,Prolactin receptor-associated protein,PRA,S100 calcium-binding protein A6,CACY,2A9,5B10,CABP,PRA
Accession:
NP_055439.1
Sequence:
Met 1-Gly 90
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human S100A6 (NP_055439.1) (Met 1-Gly 90) was expressed; with a C-terminal polyhistidine tag.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
